ACTH(4–10) raises a handful of sensible questions. This page answers them in order, starting with the fundamentals and moving to applications.
Reviewed 2026-08-01. Anything still debated is marked as such rather than presented as settled.
Scientific literature on semax is unevenly distributed. A substantial share of published work originates from a small number of laboratories in Russia, while independent replication elsewhere is limited. Human data consist mostly of small trials with short follow-up, and several reported outcomes rely on subjective rating scales. Questions about how much intact peptide reaches the central nervous system after nasal administration, and how long it persists there, are still unresolved. The compound is best described as an active research subject rather than a settled pharmacological agent.
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was derived from the ACTH(4-10) fragment, a short segment of adrenocorticotropic hormone that lacks the hormonal activity associated with the full-length peptide. Researchers at the Institute of Molecular Genetics in Moscow developed the compound during the 1980s. It has been registered as a pharmaceutical product in Russia and several neighbouring countries, where it is supplied as a nasal solution, and it is also sold internationally as a research chemical.
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is described in the literature as an analogue of the ACTH(4–10) fragment, a short N-terminal portion of adrenocorticotropic hormone that retains some neurotropic activity without the full hormonal effects of the parent peptide. The molecule carries a methionine residue at the N-terminus and two proline residues near the C-terminus, features that shape both its interactions with receptor systems and its chemical stability. The free peptide corresponds to the formula C37H51N9O10S and a molecular mass near 813.9 Da.
The compound was developed in the 1980s at the Institute of Molecular Genetics in Moscow, where it emerged from research on short ACTH fragments and their effects on the central nervous system. Russian pharmaceutical listings describe it as a nootropic and neuroprotective agent, most often formulated as nasal drops. It is not a marketed medicine in the United States or the European Union, and no pharmacopoeial monograph covers it. Consequently, most published clinical experience with the substance originates from a small number of research centres, mainly in Russia and neighbouring countries.
| Property | Value | Notes |
|---|---|---|
| Molecular formula | C37H51N9O10S | Calculated for the free peptide |
| Molar mass | 813.9 g/mol | Anhydrous free base |
| Peptide class | Synthetic heptapeptide | ACTH(4-10) analogue |
| Parent fragment | ACTH(4-10) | Adrenocorticotropic hormone segment |
| Developmental origin | Institute of Molecular Genetics, Moscow | Work began in the 1980s |
Development of the compound took place in the Soviet Union during the 1980s, largely through peptide research groups affiliated with the Shemyakin-Ovchinnikov Institute and Moscow State University. Investigators screened fragments of adrenocorticotropic hormone for activity on the central nervous system while attempting to separate cognitive effects from hormonal ones. The shortened sequence was selected because it retained behavioral activity in animal models without stimulating corticosteroid release. Early publications described the molecule as an ACTH(4-10) analog.
Published research on this peptide originates mainly from Russian laboratories, and the wider international literature is comparatively thin. Studies have used rodent models of stroke, hypoxia, and memory tasks, with a smaller number of human trials reported. Reported outcomes include changes in attention and memory measures, along with effects on neurotrophic factor expression in some experiments. Small sample sizes, inconsistent dosing protocols, and limited independent replication are widely noted limitations, so the strength of the clinical evidence remains an open question.
Semax is a synthetic heptapeptide whose sequence is Met-Glu-His-Phe-Pro-Gly-Pro. The first four residues correspond to the ACTH(4-10) fragment, while the terminal Pro-Gly-Pro extension was added to improve metabolic stability. Its molecular formula is C37H51N9O10S and its monoisotopic mass is approximately 813.9 Da. The compound is classified as a peptide research chemical and as a registered pharmaceutical product in Russia, but it does not hold marketing approval in the European Union or the United States. Naming conventions vary across supplier catalogs.
When not flying, bats hang upside down from their feet, a posture known as roosting. Most megabats roost with the head tucked towards the belly, whereas most microbats roost with the neck curled towards the back. This difference is due to the structure of the cervical or neck vertebrae in the two groups, which are clearly distinct. Tendons allow bats to hang from a roost with no effort, which is needed to release. Bats are more awkward when crawling on the ground, though a few species, such as the New Zealand lesser short-tailed bat (Mystacina tuberculata) and the common vampire bat (Desmodus rotundus), are quite agile. These species move their limbs one after the other, but vampire bats accelerate by bounding, the folded-up wings being used to propel them forward. Vampire bats likely evolved these gaits to stalk their hosts, while short-tailed bats took to the ground due to a lack of competition from other mammals. Terrestrial locomotion does not appear to affect their ability to fly.
Ibogaine's hallucinogenic effects not being mediated by serotonin 5-HT2A receptor activation has been said to be in accordance with its hallucinogenic effects in humans being qualitatively distinct from and unlike those of serotonergic psychedelics but instead similar to those of harmala alkaloids. It is also in accordance with the fact that unlike serotonergic psychedelics like LSD, neither ibogaine nor harmala alkaloids cause pupil dilation or increase blood pressure in humans. Conversely, unlike serotonergic psychedelics, ibogaine and harmaline are said to cause balance disturbances and vomiting to a greater extent than any other psychoactive drug besides alcohol. Ibogaine shows appreciable affinity for the NMDA receptor. However, the NMDA receptor antagonists phencyclidine (PCP) and dizocilpine (MK-801) fail to substitute for ibogaine and ibogaine fails to substitute for these NMDA receptor antagonists in rodents and/or monkeys. Hence, NMDA receptor antagonism does not appear to be involved in the subjective effects of ibogaine. Neither μ-opioid receptor agonists nor κ-opioid receptor agonists like U-50,488 substitute for ibogaine. In addition, the opioid antagonist naloxone did not substitute for ibogaine. However, naltrexone partially substitutes for ibogaine. In addition, the mixed opioid agonists and antagonists pentazocine, diprenorphine, and nalorphine partially substituted for ibogaine and this could be antagonized by naloxone. The preceding findings suggest a role of opioid receptors but not the NMDA receptor in the effects of ibogaine.
=== Border security === The law includes $170 billion for spending on border security, creating the capacity to deport up to one million people each year. The law increases the funding for Immigration and Customs Enforcement from $10 billion to more than $100 billion by 2029, making it the single most heavily funded law enforcement agency in the federal government. These funds include:
Arrived from Mexico on the blessed ground of this republic, whose executive powers were placed in your hands, I feel it my pleasant duty to present my respects and express my high admiration for your writings, your actions, and the liberalism of your ideas, which have inspired me from my earliest youth. I flatter myself in the expectation of expressing my sentiments orally to you, remitting at the same time the attached parcel, which my friend the Consul of the United States in Havana asked me to send to you[...] For moral reasons I could not resist seeing the United States and enjoying the consoling aspects of a people who under stand the precious gift of Liberty. I hope to be able to present my personal respects and admiration to one who contemplates philosophically the troubles of two continents. [...] I am quite unaware whether you know of me already through my work on galvanism and my publications in the memoirs of the Institut National in Paris. As a friend of science, you will excuse the indulgence of my admiration. I would love to talk to you about a subject that you have treated so ingeniously in your work on Virginia, the teeth of mammoth which we too dis covered in the Andes[...] During his wait for a response from President Jefferson, Humboldt was honored by the American Philosophical Society, of which Jefferson was the President. This society, founded in 1743 by Benjamin Franklin, was a center for scientific inquiry in the Republic. Humboldt mingled with members such as Dr.
== Synthesis == The synthesis (in this case, of carbon-14-labelled material) can be seen in figure 1. In the first step, o-nitroaniline (compound 1) is purified through dissolution in hot water-ethanol mixture in relation 2:1. [Activated carbon] is added and the result is filtrated for clarifying. The filtrate is chilled while kept in movement to generate crystals, usually at 4 °C, but if needed it can also be cooled to −10 °C. The crystals are then collected, washed and dried. If it is pure enough it is used for the following steps, which take place at 0 till 5 °C. To produce o-Nitrobenzonitrile-14C (compound 2), the first component o-nitroaniline and (concentrated reagent grade) hydrochloric acid are put together with ice and water. Sodium nitrite, dissolved in water, is added to this thin slurry. After the formation of a pale-yellow solution, which indicates the completion of the diazotization reaction, the pH should be adjusted to 6. After this, the solution is introduced to a mixture of cuprous cyanide and toluene. At room temperature the toluene layer is removed. The aqueous layer is washed and dried and the purified product is isolated by crystallization. The third product is Anthranilamide-14C (compound 3). It is formed out of o-Nitrobenzonitrile-14C, which is first solved in ethanol and hydrazine hydrate. The solvent is heated subsequently, treated in a well-ventilated hood with small periodic charges, smaller than 10 mg, of Raney nickel. Under nitrogen atmosphere the ethanolic solution is clarified and dried.
Sources: en.wikipedia.org
This advancement could allow for assisted transport, making synthetic platelets a viable option in healthcare locations with limited resources, such as rural hospitals, ambulances, and battlefield settings. While preclinical results are encouraging, challenges remain in the large-scale clinical translation of synthetic platelets. Reproducibility, large-scale production, and safety issues must be addressed to gain regulatory approval and commercial viability. Researchers continue to refine synthetic platelet formulations by maximizing circulation time, stability, and biodegradability while minimizing undesirable immune responses. Additionally, studies have shown that synthetic platelets are excreted from the body within hours if they do not reach a wound site, which reduces the risk of unintended clotting in other parts of the body.
Lt. Col. J. H. Fuller (18 April 1909 – 1 April 1911) Maj. Gordon Vallancy Drury (1 April 1911 – 28 January 1913) Maj. Gen. Sir Alfred Hamilton Mackenzie Edwards (28 January 1913 – 23 January 1923) Col. Algernon Essex Capell (1 February 1923 – 11 February 1926) Alfred James Tomlinson (12 February 1926 – 12 May 1926; acting) Col. George Stops (13 May 1926 – 14 February 1933) Brig. John Sidney Morris (15 February 1933 – 24 April 1945) Brig. John Ellis "Jack" Ross (24 April 1945 – 6 December 1950) Col. James Appleby (7 December 1950 – 2 June 1954) Col. Arthur Selwyn Hickman (3 June 1954 – 5 November 1955) Col. Harold Jackson (6 November 1955 – 12 March 1958) Basil Gordon Spurling (13 March 1958 – 25 April 1963) Frank Eric Barfoot (26 April 1963 – 2 January 1968) James Spink (3 January 1968 – 26 June 1970) Sydney Frederick Samuel Bristow (27 June 1970 – 6 February 1974) Peter Dennis Wray Richard Sherren (7 February 1974 – 6 February 1978) Peter Kevin Allum (7 February 1978 – 6 February 1982)
=== Death of Charles === Charles had been in poor health for some time. After going shopping on a chilly day in Funchal to buy toys for Carl Ludwig, he was struck by an attack of bronchitis. This rapidly worsened into pneumonia, not helped by the inadequate medical care available. Several of the children and staff were also ill, and Zita (at the time eight months pregnant) helped nurse them all. Charles weakened and died on 1 April, his last words to his wife being "I love you so much." Charles was 34 years old. After his funeral, a witness said of Zita "This woman really is to be admired. She did not, for one second, lose her composure... she greeted the people on all sides and then spoke to those who had helped out with the funeral. They were all under her charm." Zita wore mourning black in Charles's memory throughout 67 years of widowhood.
=== Physical methods === Heat treatment − Treating food with heat, such as blanching or roasting, de-naturates enzymes and destroys the reactants responsible for browning. Blanching is used, for example, in winemaking, tea processing, storing nuts and bacon, and preparing vegetables for freezing preservation. Meat is often partially browned under high heat before being incorporated into a larger preparation to be cooked at a lower temperature which produces less browning. Cold treatment − Refrigeration and freezing are the most common ways of storing food, preventing decay. The activity of browning enzymes, i.e., rate of reaction, drops in low temperatures. Thus, refrigeration helps to keep the initial look, color, and flavour of fresh vegetables and fruits. Refrigeration is also used during distribution and retailing of fruits and vegetables. Oxygen elimination − Presence of oxygen is crucial for enzymatic browning, therefore eliminating oxygen from the environment helps to slow down the browning reaction. Withdrawing air or replacing it with other gases (e.g., N2 or CO2) during preservation, such as in vacuum-packaging or modified atmosphere packaging, wine or juice bottling, using impermeable films or edible coatings, dipping into salt or sugar solutions, keeps the food away from direct contact with oxygen. Impermeable films made of plastic or other materials prevent food being exposed to oxygen in the air and avoid moisture loss.
Sources: en.wikipedia.org
==== Cancer ==== The first study on trained dogs used for the detection of cancer was published by Willis et al. in 2004, observing that dogs were capable of detecting bladder cancer from urine samples. Subsequently, in 2004, Pickel et al. confirmed that dogs were able to successfully diagnose melanoma. In 2008, Horvath et al. confirmed dogs were successful in differentiating between cancerous and normal tissue and in distinguishing non-cancerous pathological tissue from cancerous tissue. Another study by Horvath et al. in 2010 found the dogs to show over 90% specificity in detecting ovarian cancer from blood samples, colorectal cancer from respiratory air, and prostate cancer from dog urine.
=== Other uses === Risperidone has demonstrated clinical benefit as an augmentation agent in the management of (unipolar) non-psychotic treatment-resistant depression alongside antidepressant treatment. Atypical antipsychotics, such as risperidone, are among the most common augments for antidepressant therapy. Such usage occurs off-label in most jurisdictions and the risk of adverse effects (e.g., weight gain, movement disorders) must be carefully weighed against the clinical benefit. Risperidone has shown promise in treating therapy-resistant obsessive–compulsive disorder, when serotonin reuptake inhibitors alone are not sufficient. Risperidone has proven to be effective in treatment of aggression associated with attention deficit hyperactivity disorder (ADHD), or with another mental condition. Risperidone has not demonstrated a benefit in the treatment of eating disorders or personality disorders, except for limited evidence in schizotypal personality disorder.
=== Coagulation === During the fermentation process, once sufficient lactic acid has been developed, rennet is added to cause the casein to precipitate. Rennet contains the enzyme chymosin which converts κ-casein to para-κ-caseinate (the main component of cheese curd, which is a salt of one fragment of the casein) and glycomacropeptide, which is lost in the cheese whey. As the curd is formed, milk fat is trapped in a casein matrix. After adding the rennet, the cheese milk is left to form curds over a period of time.
Nuclear fission is a reaction in which the nucleus of an atom splits into two or more smaller nuclei. The fission process often produces neutrons and gamma rays, and releases a very large amount of energy even by the energetic standards of radioactive decay. The free energy released by the fission of one uranium-235 atom is about 100 million times the energy released by burning one carbon atom in air to produce CO2. Nuclear fission was discovered by chemists Otto Hahn and Fritz Strassmann and physicists Lise Meitner and Otto Robert Frisch. Hahn and Strassmann proved that a fission reaction had taken place on 19 December 1938, and Meitner and her nephew Frisch explained it theoretically in January 1939. Frisch named the process "fission" by analogy with biological fission of living cells. In their second publication on nuclear fission in February 1939, Hahn and Strassmann predicted the existence and liberation of additional neutrons during the fission process, opening up the possibility of a nuclear chain reaction by assembling a critical mass of fissile material. For heavy nuclides, it is an exothermic reaction which releases large amounts of energy both as electromagnetic radiation and as kinetic energy of the fragments (heating the bulk material where fission takes place). Like nuclear fusion, for fission to produce energy, the total binding energy of the resulting elements must be greater than that of the starting element. The fission barrier must also be overcome.
=== CAR T-cell therapy === HLA-G is both an immune checkpoint and a tumor-specific antigen, making it a target for the development of CAR T-cell therapies, which have been shown to have efficacy in in vitro mouse models. The company Invectys developed the CAR T-cell therapy IVS-3001 targeting HLA-G and began Phase1\2a clinical trials June 2023. Based on preliminary results, IVS-3001 was granted FDA fast track designation, expediting development and review of the therapy for potential use in patients with renal cell carcinoma (RCC).
Sources: en.wikipedia.org
Semax is based on the ACTH(4-10) fragment, a seven-amino-acid segment of adrenocorticotropic hormone. The synthetic peptide retains the core sequence while removing regions associated with endocrine activity. This modification is intended to isolate effects on the nervous system.
It is registered for clinical use in Russia and a few other countries, typically as a nasal drop formulation. It does not hold approval from the United States Food and Drug Administration or the European Medicines Agency. Outside those markets it is generally handled as a research chemical.
The compound was developed in Moscow and the earliest studies were conducted there, so the primary literature is largely in Russian-language journals. Translation and indexing have been incomplete, which limits access for outside researchers. Independent groups have since published some work, but the total volume remains modest.
It is described as a synthetic analogue of the ACTH(4–10) fragment, a short segment of adrenocorticotropic hormone. Its sequence differs from that fragment and includes two proline residues, which influence stability and behaviour in solution.